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HBV Target gene Detail Information

> MACF1 Gene Search Result


Gene Information
Gene Name MACF1
Gene ID 23499
Gene Alias ACF7; LIS9; MACF; OFC4; ABP620; Lnc-PMIF
Transcripts ENSG00000127603
Virus HBV
Gene Type protein coding
HPA Location Info Actin filaments;Cell Junctions;Plasma membrane;
Membrane Info Predicted membrane proteins
HPA Protein Class Info Predicted intracellular proteins, Predicted membrane proteins
Uniport_ID Q9UPN3
HGNC ID HGNC:13664
VEGA ID OTTHUMG00000007754
OMIM ID 608271
String ID 9606.ENSP00000354573
PharmGKB ID PA30518
Target gene [MACF1] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
1004116 chr1 90 2 92 View
1005177 chr1 27 19 13 59 View
1401183 chr1 27 19 13 59 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
GSE114783 (GEO) Chronic HBV (CHB) infection 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO) Hepatocellular carcinoma 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO) Liver cirrhosis 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
LIHC (TCGA) Liver hepatocellular carcinoma 424 Liver hepatocellular carcinoma HCV (HBV+)(86), Liver hepatocellular carcinoma HCV (HBV-)(19), Liver hepatocellular carcinoma (HBV+)(209), Liver hepatocellular carcinoma (HBV+)(60), Paracancerous HCV (HBV+)(4), Paracancerous (HBV-)(28), Paracancerous (HBV+)(18)

> Dataset: GSE114783

HeatMap of cell type fractions in all samples Lollipop of MACF1 expression and immune infiltrating cell level correlation result in HBV+ Chronic HBV (CHB) infection samples
MACF1 expression: Low -> High
Lollipop of MACF1 expression and immune infiltrating cell level correlation result in HBV+ Liver cirrhosis samples Lollipop of MACF1 expression and immune infiltrating cell level correlation result in HBV+ Hepatocellular carcinoma samples

> Dataset: LIHC

HeatMap of cell type fractions in all samples Lollipop of MACF1 expression and immune infiltrating cell level correlation result in HBV+ samples
MACF1 expression: Low -> High
Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).