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HBV Target gene Detail Information

> LYN Gene Search Result


Gene Information
Gene Name LYN
Gene ID 4067
Gene Full Name LYN proto-oncogene, Src family tyrosine kinase
Gene Alias JTK8; p53Lyn; p56Lyn
Transcripts ENSG00000254087
Virus HBV
Gene Type protein coding
HPA Location Info Golgi apparatus;Plasma membrane;Vesicles;
HPA Protein Class Info Cancer-related genes, Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins
Uniport_ID P07948
HGNC ID HGNC:6735
VEGA ID OTTHUMG00000044345
OMIM ID 165120
String ID 9606.ENSP00000428924
Drugbank ID BE0004315
Drug (Cytoscape Annotation) Sunitinib Malate;Vandetanib;Ibrutinib;Dasatinib;Bosutinib;Crizotinib;Gefitinib;Nilotinib;ErlotinibHydrochloride;Pazopanib Hydrochloride;ImatinibMesylate
PharmGKB ID PA30498
Target gene [LYN] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
1004162 chr8 46 21 23 90 View
1011802 chr8 7 1 8 View
1011822 chr8 7 1 8 View
1011827 chr8 7 1 8 View
1403052 chr8 46 21 23 90 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
GSE114783 (GEO) Chronic HBV (CHB) infection 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO) Hepatocellular carcinoma 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO) Liver cirrhosis 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
LIHC (TCGA) Liver hepatocellular carcinoma 424 Liver hepatocellular carcinoma HCV (HBV+)(86), Liver hepatocellular carcinoma HCV (HBV-)(19), Liver hepatocellular carcinoma (HBV+)(209), Liver hepatocellular carcinoma (HBV+)(60), Paracancerous HCV (HBV+)(4), Paracancerous (HBV-)(28), Paracancerous (HBV+)(18)

> Dataset: GSE114783

HeatMap of cell type fractions in all samples Lollipop of LYN expression and immune infiltrating cell level correlation result in HBV+ Chronic HBV (CHB) infection samples
LYN expression: Low -> High
Lollipop of LYN expression and immune infiltrating cell level correlation result in HBV+ Liver cirrhosis samples Lollipop of LYN expression and immune infiltrating cell level correlation result in HBV+ Hepatocellular carcinoma samples

> Dataset: LIHC

HeatMap of cell type fractions in all samples Lollipop of LYN expression and immune infiltrating cell level correlation result in HBV+ samples
LYN expression: Low -> High
Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).