HIV Target gene Detail Information

> LTBP4 Gene Search Result

Gene Information

Gene Name	LTBP4
Gene ID	8425
Gene Full Name	latent transforming growth factor beta binding protein 4
Gene Alias	ARCL1C; LTBP-4; LTBP4L; LTBP4S
Transcripts	ENSG00000090006
Virus	HIV
Gene Type	protein coding
HPA Location Info
HPA Protein Class Info	Disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins
Uniport_ID	Q8N2S1
HGNC ID	HGNC:6717
VEGA ID	OTTHUMG00000182635
OMIM ID	604710
String ID	9606.ENSP00000311905
PharmGKB ID	PA30480

Target gene [LTBP4] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4011725	chr19	6			6	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of LTBP4 expression and immune infiltrating cell level correlation result in HIV+ samples
LTBP4 expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of LTBP4 expression and immune infiltrating cell level correlation result in HIV+ samples
LTBP4 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).