HTLV1 Target gene Detail Information

> LSM3 Gene Search Result

Gene Information

Gene Name	LSM3
Gene ID	27258
Gene Full Name	LSM3 homolog, U6 small nuclear RNA and mRNA degradation associated
Gene Alias	SMX4; USS2; YLR438C
Transcripts	ENSG00000170860
Virus	HTLV1
Gene Type	protein coding
HPA Location Info	Nucleoli;Nucleoplasm;
HPA Protein Class Info	Plasma proteins, Predicted intracellular proteins
Uniport_ID	P62310
HGNC ID	HGNC:17874
VEGA ID	OTTHUMG00000129838
OMIM ID	607283
String ID	9606.ENSP00000302160
PharmGKB ID	PA134881991

Target gene [LSM3] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
6016871	chr3	11			11	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE55851 (GEO)	Adult T-cell leukemia	21	Normal (3), Asymptomatic carriers (HTLV1+)(6), Adult T-cell Leukemia-lymphoma (HTLV1+)(12)
GSE29312 (GEO)	HTLV-1 associated myelopathy	39	Normal (9), Asymptomatic carriers (HTLV1+)(20), HTLV-1-associated myelopathy (HTLV1+)(10)
GSE29332 (GEO)	HTLV-1 associated myelopathy	35	Normal (8), Asymptomatic carriers (HTLV1+)(17), HTLV-1-associated myelopathy (HTLV1+)(10)

> Dataset: GSE55851
HeatMap of cell type fractions in all samples	Lollipop of LSM3 expression and immune infiltrating cell level correlation result in HTLV1+ samples
LSM3 expression: Low -> High

> Dataset: GSE29312
HeatMap of cell type fractions in all samples	Lollipop of LSM3 expression and immune infiltrating cell level correlation result in HTLV1+ samples
LSM3 expression: Low -> High

> Dataset: GSE29332
HeatMap of cell type fractions in all samples	Lollipop of LSM3 expression and immune infiltrating cell level correlation result in HTLV1+ samples
LSM3 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).