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HTLV1 Target gene Detail Information

> LRRK2 Gene Search Result


Gene Information
Gene Name LRRK2
Gene ID 120892
Gene Full Name leucine rich repeat kinase 2
Gene Alias PARK8; RIPK7; ROCO2; AURA17; DARDARIN
Transcripts ENSG00000188906
Virus HTLV1
Gene Type protein coding
HPA Location Info Vesicles;
HPA Protein Class Info Cancer-related genes, Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins
Uniport_ID Q5S007
HGNC ID HGNC:18618
VEGA ID OTTHUMG00000059742
OMIM ID 609007
String ID 9606.ENSP00000298910
Drugbank ID BE0009411
PharmGKB ID PA134968052
Target gene [LRRK2] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
6002929 chr12 173 13 11 197 View
6002930 chr12 173 13 11 197 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
GSE55851 (GEO) Adult T-cell leukemia 21 Normal (3), Asymptomatic carriers (HTLV1+)(6), Adult T-cell Leukemia-lymphoma (HTLV1+)(12)
GSE29312 (GEO) HTLV-1 associated myelopathy 39 Normal (9), Asymptomatic carriers (HTLV1+)(20), HTLV-1-associated myelopathy (HTLV1+)(10)
GSE29332 (GEO) HTLV-1 associated myelopathy 35 Normal (8), Asymptomatic carriers (HTLV1+)(17), HTLV-1-associated myelopathy (HTLV1+)(10)

> Dataset: GSE55851

HeatMap of cell type fractions in all samples Lollipop of LRRK2 expression and immune infiltrating cell level correlation result in HTLV1+ samples
LRRK2 expression: Low -> High

> Dataset: GSE29312

HeatMap of cell type fractions in all samples Lollipop of LRRK2 expression and immune infiltrating cell level correlation result in HTLV1+ samples
LRRK2 expression: Low -> High

> Dataset: GSE29332

HeatMap of cell type fractions in all samples Lollipop of LRRK2 expression and immune infiltrating cell level correlation result in HTLV1+ samples
LRRK2 expression: Low -> High
Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).