HIV Target gene Detail Information

> LRRC8C Gene Search Result

Gene Information

Gene Name	LRRC8C
Gene ID	84230
Gene Full Name	leucine rich repeat containing 8 VRAC subunit C
Gene Alias	AD158; FAD158
Transcripts	ENSG00000171488
Virus	HIV
Gene Type	protein coding
HPA Location Info	Golgi apparatus;
Membrane Info	Predicted membrane proteins
HPA Protein Class Info	Predicted membrane proteins, Transporters
Uniport_ID	Q8TDW0
HGNC ID	HGNC:25075
VEGA ID	OTTHUMG00000010305
OMIM ID	612889
String ID	9606.ENSP00000359483
PharmGKB ID	PA142671536

Target gene [LRRC8C] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4000255	chr1	430	123	84	637	View
4008120	chr1	15		1	16	View
4014113	chr1		2		2	View
4014298	chr1		2		2	View
4015010	chr1	1			1	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of LRRC8C expression and immune infiltrating cell level correlation result in HIV+ samples
LRRC8C expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).