HBV Target gene Detail Information

> LRRC8B Gene Search Result

Gene Information

Gene Name	LRRC8B
Gene ID	23507
Gene Full Name	leucine rich repeat containing 8 VRAC subunit B
Gene Alias	TALRRP; TA-LRRP
Transcripts	ENSG00000197147
Virus	HBV
Gene Type	protein coding
HPA Location Info	Nuclear speckles;
Membrane Info	Predicted membrane proteins
HPA Protein Class Info	Predicted membrane proteins, Transporters
Uniport_ID	Q6P9F7
HGNC ID	HGNC:30692
VEGA ID	OTTHUMG00000010129
OMIM ID	612888
String ID	9606.ENSP00000332674
PharmGKB ID	PA142671535

Target gene [LRRC8B] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
1008422	chr1	17	3	1	21	View
1008849	chr1	14	3	2	19	View
1400380	chr1				0	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
LIHC (TCGA)	Liver hepatocellular carcinoma	424	Liver hepatocellular carcinoma HCV (HBV+)(86), Liver hepatocellular carcinoma HCV (HBV-)(19), Liver hepatocellular carcinoma (HBV+)(209), Liver hepatocellular carcinoma (HBV+)(60), Paracancerous HCV (HBV+)(4), Paracancerous (HBV-)(28), Paracancerous (HBV+)(18)

> Dataset: LIHC
HeatMap of cell type fractions in all samples	Lollipop of LRRC8B expression and immune infiltrating cell level correlation result in HBV+ samples
LRRC8B expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).