HIV Target gene Detail Information

> LRRC8A Gene Search Result

Gene Information

Gene Name	LRRC8A
Gene ID	56262
Gene Full Name	leucine rich repeat containing 8 VRAC subunit A
Gene Alias	AGM5; LRRC8; SWELL1
Transcripts	ENSG00000136802
Virus	HIV
Gene Type	protein coding
HPA Location Info
Membrane Info	Predicted membrane proteins
HPA Protein Class Info	Disease related genes, Plasma proteins, Potential drug targets, Predicted membrane proteins, Transporters
Uniport_ID	Q8IWT6
HGNC ID	HGNC:19027
VEGA ID	OTTHUMG00000020766
OMIM ID	608360
String ID	9606.ENSP00000259324
PharmGKB ID	PA134909315

Target gene [LRRC8A] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4000112	chr9	230	400	397	1027	View
4002767	chr9	68	11	1	80	View
4004622	chr9	31	10		41	View
4009860	chr9	10			10	View
4010360	chr9	5	4		9	View
4014800	chr9	2			2	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of LRRC8A expression and immune infiltrating cell level correlation result in HIV+ samples
LRRC8A expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of LRRC8A expression and immune infiltrating cell level correlation result in HIV+ samples
LRRC8A expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).