HIV Target gene Detail Information

> LRRC14 Gene Search Result

Gene Information

Gene Name	LRRC14
Gene ID	9684
Gene Full Name	leucine rich repeat containing 14
Gene Alias	LRRC14A
Transcripts	ENSG00000160959
Virus	HIV
Gene Type	protein coding
HPA Location Info	Cytosol;Nucleoplasm;
HPA Protein Class Info	Predicted intracellular proteins
Uniport_ID	Q15048
HGNC ID	HGNC:20419
VEGA ID	OTTHUMG00000165179
String ID	9606.ENSP00000292524
PharmGKB ID	PA134914089

Target gene [LRRC14] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4001231	chr8	190	1		191	View
4001293	chr8	163	19		182	View
4001294	chr8	163	19		182	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of LRRC14 expression and immune infiltrating cell level correlation result in HIV+ samples
LRRC14 expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of LRRC14 expression and immune infiltrating cell level correlation result in HIV+ samples
LRRC14 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).