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HBV Target gene Detail Information

> LRCH3 Gene Search Result


Gene Information
Gene Name LRCH3
Gene ID 84859
Gene Full Name leucine rich repeats and calponin homology domain containing 3
Transcripts ENSG00000186001
Virus HBV
Gene Type protein coding
HPA Location Info Cytosol;Predicted to be secreted;
Membrane Info Predicted membrane proteins
HPA Protein Class Info Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins
Uniport_ID Q96II8
HGNC ID HGNC:28637
VEGA ID OTTHUMG00000155378
String ID 9606.ENSP00000334375
PharmGKB ID PA134923024
Target gene [LRCH3] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
1007647 chr3 23 2 25 View
1009828 chr3 14 14 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
GSE114783 (GEO) Chronic HBV (CHB) infection 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO) Hepatocellular carcinoma 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO) Liver cirrhosis 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
LIHC (TCGA) Liver hepatocellular carcinoma 424 Liver hepatocellular carcinoma HCV (HBV+)(86), Liver hepatocellular carcinoma HCV (HBV-)(19), Liver hepatocellular carcinoma (HBV+)(209), Liver hepatocellular carcinoma (HBV+)(60), Paracancerous HCV (HBV+)(4), Paracancerous (HBV-)(28), Paracancerous (HBV+)(18)

> Dataset: GSE114783

HeatMap of cell type fractions in all samples Lollipop of LRCH3 expression and immune infiltrating cell level correlation result in HBV+ Chronic HBV (CHB) infection samples
LRCH3 expression: Low -> High
Lollipop of LRCH3 expression and immune infiltrating cell level correlation result in HBV+ Liver cirrhosis samples Lollipop of LRCH3 expression and immune infiltrating cell level correlation result in HBV+ Hepatocellular carcinoma samples

> Dataset: LIHC

HeatMap of cell type fractions in all samples Lollipop of LRCH3 expression and immune infiltrating cell level correlation result in HBV+ samples
LRCH3 expression: Low -> High
Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).