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HPV Target gene Detail Information

> LRAT Gene Search Result


Gene Information
Gene Name LRAT
Gene ID 9227
Gene Full Name lecithin retinol acyltransferase
Gene Alias LCA14
Transcripts ENSG00000121207
Virus HPV
Gene Type protein coding
HPA Location Info Golgi apparatus;Endoplasmic reticulum;
Membrane Info Predicted membrane proteins
HPA Protein Class Info Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins
Uniport_ID O95237
HGNC ID HGNC:6685
VEGA ID OTTHUMG00000161418
OMIM ID 604863
String ID 9606.ENSP00000337224
Drugbank ID BE0000900
PharmGKB ID PA30443
Target gene [LRAT] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
5200622 chr4 15 15 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
GSE140662 (GEO) Condyloma Acuminatum 8 Condyloma acuminata (HPV+)(5), Skin(3)
GSE65858 (GEO) Head and neck squamous cell carcinoma 270 Head and neck squamous cell carcinoma (EBV+)(73), Head and neck squamous cell carcinoma (EBV-)(197)
GSE55546 (GEO) Oropharyngeal squamous cell carcinoma 16 Oropharyngeal cancers (HPV+)(12), Normal (4)
GSE55544 (GEO) Oropharyngeal squamous cell carcinoma 23 Oropharyngeal cancers HPV Active (11), Oropharyngeal cancers HPV Inactive (4), Oropharyngeal cancers HPV Negative (8)
GSE55542 (GEO) Oropharyngeal squamous cell carcinoma 36 Oropharyngeal cancers HPV Active (12), Oropharyngeal cancers HPV Inactive (8), Oropharyngeal cancers HPV Negative (16)
GSE51993 (GEO) Cervical intraepithelial neoplasia 24 Cervical intraepithelial neoplasia (HPV+)(17), Normal(7)
HNSC (TCGA) Head and Neck squamous cell carcinoma 566 Head and Neck squamous cell carcinoma(HPV-)(483),Head and Neck squamous cell carcinoma(HPV+)(39),Paracancerous(HPV-)(44)

> Dataset: GSE140662

HeatMap of cell type fractions in all samples Lollipop of LRAT expression and immune infiltrating cell level correlation result in HPV+ samples
LRAT expression: Low -> High

> Dataset: GSE65858

HeatMap of cell type fractions in all samples Lollipop of LRAT expression and immune infiltrating cell level correlation result in HPV+ samples
LRAT expression: Low -> High

> Dataset: GSE55546

HeatMap of cell type fractions in all samples Lollipop of LRAT expression and immune infiltrating cell level correlation result in HPV+ samples
LRAT expression: Low -> High

> Dataset: GSE55544

HeatMap of cell type fractions in all samples Lollipop of LRAT expression and immune infiltrating cell level correlation result in HPV+ samples
LRAT expression: Low -> High

> Dataset: GSE55542

HeatMap of cell type fractions in all samples Lollipop of LRAT expression and immune infiltrating cell level correlation result in HPV+ samples
LRAT expression: Low -> High

> Dataset: GSE51993

HeatMap of cell type fractions in all samples Lollipop of LRAT expression and immune infiltrating cell level correlation result in HPV+ samples
LRAT expression: Low -> High

> Dataset: HNSC

HeatMap of cell type fractions in all samples Lollipop of LRAT expression and immune infiltrating cell level correlation result in HPV+ samples
LRAT expression: Low -> High
Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).