HIV Target gene Detail Information

> LMTK2 Gene Search Result

Gene Information

Gene Name	LMTK2
Gene ID	22853
Gene Full Name	lemur tyrosine kinase 2
Gene Alias	BREK; KPI2; LMR2; cprk; KPI-2; hBREK; AATYK2; PPP1R100
Transcripts	ENSG00000164715
Virus	HIV
Gene Type	protein coding
HPA Location Info	Centriolar satellite;Nuclear speckles;Cytosol;Plasma membrane;
Membrane Info	Predicted membrane proteins
HPA Protein Class Info	Enzymes, Predicted membrane proteins
Uniport_ID	Q8IWU2
HGNC ID	HGNC:17880
VEGA ID	OTTHUMG00000154256
OMIM ID	610989
String ID	9606.ENSP00000297293
PharmGKB ID	PA134884391

Target gene [LMTK2] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4000376	chr7	297	72	134	503	View
4001789	chr7	81	41	10	132	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of LMTK2 expression and immune infiltrating cell level correlation result in HIV+ samples
LMTK2 expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of LMTK2 expression and immune infiltrating cell level correlation result in HIV+ samples
LMTK2 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).