HPV Target gene Detail Information

> LLPH Gene Search Result

Gene Information

Gene Name	LLPH
Gene ID	84298
Gene Full Name	LLP homolog, long-term synaptic facilitation factor
Gene Alias	hLLP; C12orf31
Transcripts	ENSG00000139233
Virus	HPV
Gene Type	protein coding
HPA Location Info	Nucleoli;Mitotic chromosome;
HPA Protein Class Info	Predicted intracellular proteins
Uniport_ID	Q9BRT6
HGNC ID	HGNC:28229
VEGA ID	OTTHUMG00000168959
OMIM ID	616998
String ID	9606.ENSP00000266604
PharmGKB ID	PA164722116

Target gene [LLPH] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
5402569	chr12	29	35	3	67	View
5402980	chr12	24	29	3	56	View
5402984	chr12	24	29	3	56	View
5403381	chr12	24	29	3	56	View
5403438	chr12	24	29	3	56	View
5403439	chr12	29	35	3	67	View
5403494	chr12	24	29	3	56	View
5403495	chr12	29	35	3	67	View
5403505	chr12	24	29	3	56	View
5404302	chr12	24	29	3	56	View
5404325	chr12	24	29	3	56	View
5404484	chr12	24	29	3	56	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE65858 (GEO)	Head and neck squamous cell carcinoma	270	Head and neck squamous cell carcinoma (EBV+)(73), Head and neck squamous cell carcinoma (EBV-)(197)
GSE40774 (GEO)	Head and neck squamous cell carcinoma	134	Head and neck Squamous cell carcinomas GLOTTIC LARYNX (EBV-)(2), Head and neck Squamous cell carcinomas HYPOPHARYNX (EBV-)(9), Head and neck Squamous cell carcinomas ORAL CAVITY (EBV-)(23), Head and neck Squamous cell carcinomas ORAL CAVITY (EBV+)(2), Head and neck Squamous cell carcinomas OROPHARYNX (EBV-)(22), Head and neck Squamous cell carcinomas OROPHARYNX (EBV+)(54), Head and neck Squamous cell carcinomas OTHER (EBV+)(1), Head and neck Squamous cell carcinomas SUBGLOTTIC LARYNX (EBV-)(1), Head and neck Squamous cell carcinomas SUPRAGLOTTIC (EBV-)(19), Squamous cell carcinomas SUPRAGLOTTIC (EBV+)(1)
GSE138080 (GEO)	Cervical intraepithelial neoplasia	25	Normal (10), Cervical intraepithelial neoplasia (HPV+)(15)
GSE51993 (GEO)	Cervical intraepithelial neoplasia	24	Cervical intraepithelial neoplasia (HPV+)(17), Normal(7)
HNSC (TCGA)	Head and Neck squamous cell carcinoma	566	Head and Neck squamous cell carcinoma(HPV-)(483),Head and Neck squamous cell carcinoma(HPV+)(39),Paracancerous(HPV-)(44)

> Dataset: GSE65858
HeatMap of cell type fractions in all samples	Lollipop of LLPH expression and immune infiltrating cell level correlation result in HPV+ samples
LLPH expression: Low -> High

> Dataset: GSE40774
HeatMap of cell type fractions in all samples	Lollipop of LLPH expression and immune infiltrating cell level correlation result in HPV+ samples
LLPH expression: Low -> High

> Dataset: GSE138080
HeatMap of cell type fractions in all samples	Lollipop of LLPH expression and immune infiltrating cell level correlation result in HPV+ samples
LLPH expression: Low -> High

> Dataset: GSE51993
HeatMap of cell type fractions in all samples	Lollipop of LLPH expression and immune infiltrating cell level correlation result in HPV+ samples
LLPH expression: Low -> High

> Dataset: HNSC
HeatMap of cell type fractions in all samples	Lollipop of LLPH expression and immune infiltrating cell level correlation result in HPV+ samples
LLPH expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).

> Dataset: GSE65858