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HTLV1 Target gene Detail Information

> LIN7A Gene Search Result


Gene Information
Gene Name LIN7A
Gene ID 8825
Gene Full Name lin-7 homolog A, crumbs cell polarity complex component
Gene Alias LIN7; MALS1; VELI1; LIN-7A; MALS-1; TIP-33
Transcripts ENSG00000111052
Virus HTLV1
Gene Type protein coding
HPA Location Info
HPA Protein Class Info Predicted intracellular proteins
Uniport_ID O14910
HGNC ID HGNC:17787
VEGA ID OTTHUMG00000170168
OMIM ID 603380
String ID 9606.ENSP00000447488
PharmGKB ID PA134881936
Target gene [LIN7A] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
6002818 chr12 9 195 3 207 View
6005164 chr12 13 77 4 94 View
6006070 chr12 10 51 14 75 View
6017676 chr12 10 10 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
GSE55851 (GEO) Adult T-cell leukemia 21 Normal (3), Asymptomatic carriers (HTLV1+)(6), Adult T-cell Leukemia-lymphoma (HTLV1+)(12)
GSE29312 (GEO) HTLV-1 associated myelopathy 39 Normal (9), Asymptomatic carriers (HTLV1+)(20), HTLV-1-associated myelopathy (HTLV1+)(10)
GSE29332 (GEO) HTLV-1 associated myelopathy 35 Normal (8), Asymptomatic carriers (HTLV1+)(17), HTLV-1-associated myelopathy (HTLV1+)(10)

> Dataset: GSE55851

HeatMap of cell type fractions in all samples Lollipop of LIN7A expression and immune infiltrating cell level correlation result in HTLV1+ samples
LIN7A expression: Low -> High

> Dataset: GSE29312

HeatMap of cell type fractions in all samples Lollipop of LIN7A expression and immune infiltrating cell level correlation result in HTLV1+ samples
LIN7A expression: Low -> High

> Dataset: GSE29332

HeatMap of cell type fractions in all samples Lollipop of LIN7A expression and immune infiltrating cell level correlation result in HTLV1+ samples
LIN7A expression: Low -> High
Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).