HIV Target gene Detail Information

> LIMA1 Gene Search Result

Gene Information

Gene Name	LIMA1
Gene ID	51474
Gene Full Name	LIM domain and actin binding 1
Gene Alias	EPLIN; LDLCQ8; SREBP3
Transcripts	ENSG00000050405
Virus	HIV
Gene Type	protein coding
HPA Location Info	Actin filaments;Plasma membrane;Cytosol;Focal adhesion sites;
HPA Protein Class Info	Predicted intracellular proteins
Gene Function	Suppressor gene
Uniport_ID	Q9UHB6
HGNC ID	HGNC:24636
VEGA ID	OTTHUMG00000169852
OMIM ID	608364
String ID	9606.ENSP00000378400
PharmGKB ID	PA143485527

Target gene [LIMA1] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4000050	chr12	340	771	482	1593	View
4000218	chr12	252	188	272	712	View
4000427	chr12	92	323	55	470	View
4000630	chr12	253	59	26	338	View
4002009	chr12	63	27	28	118	View
4012875	chr12	1	3		4	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of LIMA1 expression and immune infiltrating cell level correlation result in HIV+ samples
LIMA1 expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of LIMA1 expression and immune infiltrating cell level correlation result in HIV+ samples
LIMA1 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).