HBV Target gene Detail Information

> LIG3 Gene Search Result

Gene Information

Gene Name	LIG3
Gene ID	3980
Gene Full Name	DNA ligase 3
Gene Alias	LIG2; LIG3alpha
Transcripts	ENSG00000005156
Virus	HBV
Gene Type	protein coding
HPA Location Info	Nucleoplasm;
HPA Protein Class Info	Enzymes, Plasma proteins, Predicted intracellular proteins
Uniport_ID	P49916
HGNC ID	HGNC:6600
VEGA ID	OTTHUMG00000128519
OMIM ID	600940
String ID	9606.ENSP00000367787
Drugbank ID	BE0000167
PharmGKB ID	PA30374

Target gene [LIG3] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
1400296	chr17	1			1	View
1400508	chr6	1	3		4	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
LIHC (TCGA)	Liver hepatocellular carcinoma	424	Liver hepatocellular carcinoma HCV (HBV+)(86), Liver hepatocellular carcinoma HCV (HBV-)(19), Liver hepatocellular carcinoma (HBV+)(209), Liver hepatocellular carcinoma (HBV+)(60), Paracancerous HCV (HBV+)(4), Paracancerous (HBV-)(28), Paracancerous (HBV+)(18)

> Dataset: LIHC
HeatMap of cell type fractions in all samples	Lollipop of LIG3 expression and immune infiltrating cell level correlation result in HBV+ samples
LIG3 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).