HIV Target gene Detail Information

> LETM1 Gene Search Result

Gene Information

Gene Name	LETM1
Gene ID	3954
Gene Full Name	leucine zipper and EF-hand containing transmembrane protein 1
Gene Alias	SLC55A1
Transcripts	ENSG00000168924
Virus	HIV
Gene Type	protein coding
HPA Location Info	Mitochondria;
Membrane Info	Predicted membrane proteins
HPA Protein Class Info	Predicted membrane proteins, Transporters
Uniport_ID	O95202
HGNC ID	HGNC:6556
VEGA ID	OTTHUMG00000121149
OMIM ID	604407
String ID	9606.ENSP00000305653
PharmGKB ID	PA30335

Target gene [LETM1] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4009965	chr4	9	1		10	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of LETM1 expression and immune infiltrating cell level correlation result in HIV+ samples
LETM1 expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of LETM1 expression and immune infiltrating cell level correlation result in HIV+ samples
LETM1 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).