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HBV Target gene Detail Information

> LEPR Gene Search Result


Gene Information
Gene Name LEPR
Gene ID 3953
Gene Full Name leptin receptor
Gene Alias OBR; OB-R; CD295; LEP-R; LEPRD
Transcripts ENSG00000116678
Virus HBV
Gene Type protein coding
HPA Location Info
Membrane Info Predicted membrane proteins
HPA Protein Class Info Cancer-related genes, Candidate cardiovascular disease genes, CD markers, Disease related genes, FDA approved drug targets, Plasma proteins, Predicted membrane proteins, Predicted secreted proteins
Uniport_ID P48357
HGNC ID HGNC:6554
VEGA ID OTTHUMG00000009115
OMIM ID 601007
String ID 9606.ENSP00000330393
Drugbank ID BE0003376
PharmGKB ID PA229
FDA Approved Drug Setmelanotide
Target gene [LEPR] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
1003076 chr1 55 30 83 168 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
LIHC (TCGA) Liver hepatocellular carcinoma 424 Liver hepatocellular carcinoma HCV (HBV+)(86), Liver hepatocellular carcinoma HCV (HBV-)(19), Liver hepatocellular carcinoma (HBV+)(209), Liver hepatocellular carcinoma (HBV+)(60), Paracancerous HCV (HBV+)(4), Paracancerous (HBV-)(28), Paracancerous (HBV+)(18)

> Dataset: LIHC

HeatMap of cell type fractions in all samples Lollipop of LEPR expression and immune infiltrating cell level correlation result in HBV+ samples
LEPR expression: Low -> High
Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).