HTLV1 Target gene Detail Information

> LENG8 Gene Search Result

Gene Information

Gene Name	LENG8
Gene ID	114823
Gene Full Name	leukocyte receptor cluster member 8
Gene Alias	pp13842
Transcripts	ENSG00000276458
Virus	HTLV1
Gene Type	protein coding
HPA Location Info	Nucleoplasm;Cytosol;
Membrane Info	Predicted membrane proteins
HPA Protein Class Info	Predicted intracellular proteins, Predicted membrane proteins
Uniport_ID	Q96PV6
HGNC ID	HGNC:15500
VEGA ID	OTTHUMG00000152706
OMIM ID	616575
String ID	9606.ENSP00000318374
PharmGKB ID	PA134903953

Target gene [LENG8] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
6004062	chr19	76	18	36	130	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE55851 (GEO)	Adult T-cell leukemia	21	Normal (3), Asymptomatic carriers (HTLV1+)(6), Adult T-cell Leukemia-lymphoma (HTLV1+)(12)
GSE29312 (GEO)	HTLV-1 associated myelopathy	39	Normal (9), Asymptomatic carriers (HTLV1+)(20), HTLV-1-associated myelopathy (HTLV1+)(10)
GSE29332 (GEO)	HTLV-1 associated myelopathy	35	Normal (8), Asymptomatic carriers (HTLV1+)(17), HTLV-1-associated myelopathy (HTLV1+)(10)

> Dataset: GSE55851
HeatMap of cell type fractions in all samples	Lollipop of LENG8 expression and immune infiltrating cell level correlation result in HTLV1+ samples
LENG8 expression: Low -> High

> Dataset: GSE29312
HeatMap of cell type fractions in all samples	Lollipop of LENG8 expression and immune infiltrating cell level correlation result in HTLV1+ samples
LENG8 expression: Low -> High

> Dataset: GSE29332
HeatMap of cell type fractions in all samples	Lollipop of LENG8 expression and immune infiltrating cell level correlation result in HTLV1+ samples
LENG8 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).