HIV Target gene Detail Information

> LEF1 Gene Search Result

Gene Information

Gene Name	LEF1
Gene ID	51176
Gene Full Name	lymphoid enhancer binding factor 1
Gene Alias	LEF-1; TCF10; TCF7L3; TCF1ALPHA
Transcripts	ENSG00000138795
Virus	HIV
Gene Type	protein coding
HPA Location Info	Nucleoplasm;
HPA Protein Class Info	Cancer-related genes, Plasma proteins, Predicted intracellular proteins, Transcription factors
Gene Function	Oncogene
Uniport_ID	Q9UJU2
HGNC ID	HGNC:6551
VEGA ID	OTTHUMG00000131809
OMIM ID	153245
String ID	9606.ENSP00000265165
Drugbank ID	BE0008936
PharmGKB ID	PA30331

Target gene [LEF1] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4002090	chr4	111	2		113	View
4003119	chr4	22	34	13	69	View
4005004	chr4	2	29	6	37	View
4007270	chr4	3		17	20	View
4007682	chr4	9	9		18	View
4010330	chr4	9			9	View
4011259	chr4	3	4		7	View
4012162	chr4	5			5	View
4014015	chr4		3		3	View
4015400	chr4	1			1	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of LEF1 expression and immune infiltrating cell level correlation result in HIV+ samples
LEF1 expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of LEF1 expression and immune infiltrating cell level correlation result in HIV+ samples
LEF1 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).