HIV Target gene Detail Information

> LDLR Gene Search Result

Gene Information

Gene Name	LDLR
Gene ID	3949
Gene Full Name	low density lipoprotein receptor
Gene Alias	FH; FHC; LDLCQ2
Transcripts	ENSG00000130164
Virus	HIV
Gene Type	protein coding
HPA Location Info
Membrane Info	Predicted membrane proteins
HPA Protein Class Info	Disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins
Uniport_ID	P01130
HGNC ID	HGNC:6547
VEGA ID	OTTHUMG00000171935
OMIM ID	606945
String ID	9606.ENSP00000454071
Drugbank ID	BE0000499
PharmGKB ID	PA227

Target gene [LDLR] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4001973	chr19	54	60	6	120	View
4008463	chr19	15			15	View
4010205	chr19	7	1	1	9	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of LDLR expression and immune infiltrating cell level correlation result in HIV+ samples
LDLR expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of LDLR expression and immune infiltrating cell level correlation result in HIV+ samples
LDLR expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).