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HTLV1 Target gene Detail Information

> LCT Gene Search Result


Gene Information
Gene Name LCT
Gene ID 3938
Gene Full Name lactase
Gene Alias LAC; LPH; LPH1
Transcripts ENSG00000115850
Virus HTLV1
Gene Type protein coding
HPA Location Info
Membrane Info Predicted membrane proteins
HPA Protein Class Info Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted membrane proteins
Uniport_ID P09848
HGNC ID HGNC:6530
VEGA ID OTTHUMG00000131738
OMIM ID 603202
String ID 9606.ENSP00000264162
Drugbank ID BE0004338
PharmGKB ID PA30315
Target gene [LCT] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
6006608 chr13 60 6 66 View
6011757 chr13 25 25 View
6014877 chr13 14 1 15 View
6023115 chr2 3 1 4 View
6023677 chr13 4 4 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
GSE55851 (GEO) Adult T-cell leukemia 21 Normal (3), Asymptomatic carriers (HTLV1+)(6), Adult T-cell Leukemia-lymphoma (HTLV1+)(12)
GSE29312 (GEO) HTLV-1 associated myelopathy 39 Normal (9), Asymptomatic carriers (HTLV1+)(20), HTLV-1-associated myelopathy (HTLV1+)(10)
GSE29332 (GEO) HTLV-1 associated myelopathy 35 Normal (8), Asymptomatic carriers (HTLV1+)(17), HTLV-1-associated myelopathy (HTLV1+)(10)

> Dataset: GSE55851

HeatMap of cell type fractions in all samples Lollipop of LCT expression and immune infiltrating cell level correlation result in HTLV1+ samples
LCT expression: Low -> High

> Dataset: GSE29312

HeatMap of cell type fractions in all samples Lollipop of LCT expression and immune infiltrating cell level correlation result in HTLV1+ samples
LCT expression: Low -> High

> Dataset: GSE29332

HeatMap of cell type fractions in all samples Lollipop of LCT expression and immune infiltrating cell level correlation result in HTLV1+ samples
LCT expression: Low -> High
Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).