HTLV1 Target gene Detail Information

> LCA5 Gene Search Result

Gene Information

Gene Name	LCA5
Gene ID	167691
Gene Full Name	LCA5, lebercilin
Gene Alias	C6orf152
Transcripts	ENSG00000135338
Virus	HTLV1
Gene Type	protein coding
HPA Location Info
HPA Protein Class Info	Disease related genes, Predicted intracellular proteins
Uniport_ID	Q86VQ0
HGNC ID	HGNC:31923
VEGA ID	OTTHUMG00000015080
OMIM ID	611408
String ID	9606.ENSP00000376686
PharmGKB ID	PA142671563

Target gene [LCA5] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
6003301	chr6	38	126	4	168	View
6009968	chr6	2	32		34	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE55851 (GEO)	Adult T-cell leukemia	21	Normal (3), Asymptomatic carriers (HTLV1+)(6), Adult T-cell Leukemia-lymphoma (HTLV1+)(12)
GSE29312 (GEO)	HTLV-1 associated myelopathy	39	Normal (9), Asymptomatic carriers (HTLV1+)(20), HTLV-1-associated myelopathy (HTLV1+)(10)

> Dataset: GSE55851
HeatMap of cell type fractions in all samples	Lollipop of LCA5 expression and immune infiltrating cell level correlation result in HTLV1+ samples
LCA5 expression: Low -> High

> Dataset: GSE29312
HeatMap of cell type fractions in all samples	Lollipop of LCA5 expression and immune infiltrating cell level correlation result in HTLV1+ samples
LCA5 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).