HIV Target gene Detail Information

> LASP1 Gene Search Result

Gene Information

Gene Name	LASP1
Gene ID	3927
Gene Full Name	LIM and SH3 protein 1
Gene Alias	MLN50; Lasp-1
Transcripts	ENSG00000002834
Virus	HIV
Gene Type	protein coding
HPA Location Info	Cytosol;Plasma membrane;Focal adhesion sites;
HPA Protein Class Info	Cancer-related genes, Plasma proteins, Predicted intracellular proteins
Uniport_ID	Q14847
HGNC ID	HGNC:6513
VEGA ID	OTTHUMG00000133182
OMIM ID	602920
String ID	9606.ENSP00000325240
PharmGKB ID	PA30298

Target gene [LASP1] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4000481	chr17	219	189	26	434	View
4000766	chr2	34	216	37	287	View
4004281	chr17	45	1		46	View
4006883	chr2	21	1		22	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of LASP1 expression and immune infiltrating cell level correlation result in HIV+ samples
LASP1 expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of LASP1 expression and immune infiltrating cell level correlation result in HIV+ samples
LASP1 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).