HTLV1 Target gene Detail Information

> LAP3 Gene Search Result

Gene Information

Gene Name	LAP3
Gene ID	51056
Gene Full Name	leucine aminopeptidase 3
Gene Alias	LAP; PEPS; LAPEP; HEL-S-106
Transcripts	ENSG00000002549
Virus	HTLV1
Gene Type	protein coding
HPA Location Info	Cytosol;Midbody;Nucleoplasm;
HPA Protein Class Info	Enzymes, Plasma proteins, Predicted intracellular proteins
Uniport_ID	P28838
HGNC ID	HGNC:18449
VEGA ID	OTTHUMG00000048214
OMIM ID	170250
String ID	9606.ENSP00000226299
Drugbank ID	BE0003882
PharmGKB ID	PA38537

Target gene [LAP3] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
6010990	chr4	14	14		28	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE55851 (GEO)	Adult T-cell leukemia	21	Normal (3), Asymptomatic carriers (HTLV1+)(6), Adult T-cell Leukemia-lymphoma (HTLV1+)(12)
GSE29312 (GEO)	HTLV-1 associated myelopathy	39	Normal (9), Asymptomatic carriers (HTLV1+)(20), HTLV-1-associated myelopathy (HTLV1+)(10)
GSE29332 (GEO)	HTLV-1 associated myelopathy	35	Normal (8), Asymptomatic carriers (HTLV1+)(17), HTLV-1-associated myelopathy (HTLV1+)(10)

> Dataset: GSE55851
HeatMap of cell type fractions in all samples	Lollipop of LAP3 expression and immune infiltrating cell level correlation result in HTLV1+ samples
LAP3 expression: Low -> High

> Dataset: GSE29312
HeatMap of cell type fractions in all samples	Lollipop of LAP3 expression and immune infiltrating cell level correlation result in HTLV1+ samples
LAP3 expression: Low -> High

> Dataset: GSE29332
HeatMap of cell type fractions in all samples	Lollipop of LAP3 expression and immune infiltrating cell level correlation result in HTLV1+ samples
LAP3 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).