HBV Target gene Detail Information

> KSR1 Gene Search Result

Gene Information

Gene Name	KSR1
Gene ID	8844
Gene Full Name	kinase suppressor of ras 1
Gene Alias	KSR; RSU2
Transcripts	ENSG00000141068
Virus	HBV
Gene Type	protein coding
HPA Location Info
HPA Protein Class Info	Enzymes, Predicted intracellular proteins, RAS pathway related proteins
Uniport_ID	Q8IVT5
HGNC ID	HGNC:6465
VEGA ID	OTTHUMG00000132051
OMIM ID	601132
String ID	9606.ENSP00000381958
PharmGKB ID	PA30254

Target gene [KSR1] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
1002557	chr17	186	49	13	248	View
1002570	chr17	188	45	12	245	View
1002571	chr17	188	45	12	245	View
1402737	chr17	188	45	12	245	View
1402965	chr17	188	45	12	245	View
1402966	chr17	186	49	13	248	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE114783 (GEO)	Chronic HBV (CHB) infection	36	Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO)	Hepatocellular carcinoma	36	Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO)	Liver cirrhosis	36	Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
LIHC (TCGA)	Liver hepatocellular carcinoma	424	Liver hepatocellular carcinoma HCV (HBV+)(86), Liver hepatocellular carcinoma HCV (HBV-)(19), Liver hepatocellular carcinoma (HBV+)(209), Liver hepatocellular carcinoma (HBV+)(60), Paracancerous HCV (HBV+)(4), Paracancerous (HBV-)(28), Paracancerous (HBV+)(18)

> Dataset: GSE114783
HeatMap of cell type fractions in all samples	Lollipop of KSR1 expression and immune infiltrating cell level correlation result in HBV+ Chronic HBV (CHB) infection samples
KSR1 expression: Low -> High
Lollipop of KSR1 expression and immune infiltrating cell level correlation result in HBV+ Liver cirrhosis samples	Lollipop of KSR1 expression and immune infiltrating cell level correlation result in HBV+ Hepatocellular carcinoma samples


> Dataset: LIHC
HeatMap of cell type fractions in all samples	Lollipop of KSR1 expression and immune infiltrating cell level correlation result in HBV+ samples
KSR1 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).