HIV Target gene Detail Information

> KPNB1 Gene Search Result

Gene Information

Gene Name	KPNB1
Gene ID	3837
Gene Full Name	karyopherin subunit beta 1
Gene Alias	IMB1; IPO1; IPOB; Impnb; NTF97
Transcripts	ENSG00000108424
Virus	HIV
Gene Type	protein coding
HPA Location Info	Nuclear membrane;Cytosol;Nucleoplasm;
HPA Protein Class Info	Plasma proteins, Predicted intracellular proteins, Transporters
Uniport_ID	Q14974
HGNC ID	HGNC:6400
VEGA ID	OTTHUMG00000036957
OMIM ID	602738
String ID	9606.ENSP00000290158
PharmGKB ID	PA30191

Target gene [KPNB1] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4003437	chr17	42	19		61	View
4005301	chr17	20	14		34	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of KPNB1 expression and immune infiltrating cell level correlation result in HIV+ samples
KPNB1 expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of KPNB1 expression and immune infiltrating cell level correlation result in HIV+ samples
KPNB1 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).