HIV Target gene Detail Information

> KNTC1 Gene Search Result

Gene Information

Gene Name	KNTC1
Gene ID	9735
Gene Full Name	kinetochore associated 1
Gene Alias	ROD
Transcripts	ENSG00000184445
Virus	HIV
Gene Type	protein coding
HPA Location Info	Cytosol;Plasma membrane;
HPA Protein Class Info	Plasma proteins, Predicted intracellular proteins
Uniport_ID	P50748
HGNC ID	HGNC:17255
VEGA ID	OTTHUMG00000168861
OMIM ID	607363
String ID	9606.ENSP00000328236
PharmGKB ID	PA30184

Target gene [KNTC1] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4001359	chr12	172	2		174	View
4006738	chr12	17	6		23	View
4007656	chr12	10	8		18	View
4007965	chr12	17			17	View
4010150	chr12	9			9	View
4010282	chr12	8	1		9	View
4011697	chr12	3	3		6	View
4012217	chr12	5			5	View
4012396	chr12	4	1		5	View
4012708	chr12	4			4	View
4012881	chr12	3	1		4	View
4013785	chr12		3		3	View
4014685	chr12	2			2	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of KNTC1 expression and immune infiltrating cell level correlation result in HIV+ samples
KNTC1 expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of KNTC1 expression and immune infiltrating cell level correlation result in HIV+ samples
KNTC1 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).