HIV Target gene Detail Information

> KMT2C Gene Search Result

Gene Information

Gene Name	KMT2C
Gene ID	58508
Gene Full Name	lysine methyltransferase 2C
Gene Alias	HALR; MLL3; KLEFS2
Transcripts	ENSG00000055609
Virus	HIV
Gene Type	protein coding
HPA Location Info	Nucleoplasm;
HPA Protein Class Info	Cancer-related genes, Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins
Gene Function	Suppressor gene
Uniport_ID	Q8NEZ4
HGNC ID	HGNC:13726
VEGA ID	OTTHUMG00000150553
OMIM ID	606833
String ID	9606.ENSP00000262189
PharmGKB ID	PA30847

Target gene [KMT2C] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4000736	chr7	94	79	126	299	View
4001239	chr7	185	5		190	View
4001748	chr7	110	5	20	135	View
4008209	chr7	15	1		16	View
4008982	chr7	13			13	View
4010641	chr7	7	1		8	View
4014644	chr7	1	1		2	View
4016676	chr7				0	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of KMT2C expression and immune infiltrating cell level correlation result in HIV+ samples
KMT2C expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).