HIV Target gene Detail Information

> KMT2A Gene Search Result

Gene Information

Gene Name	KMT2A
Gene ID	4297
Gene Full Name	lysine methyltransferase 2A
Gene Alias	HRX; MLL; MLL1; TRX1; ALL-1; CXXC7; HTRX1; MLL1A; WDSTS
Transcripts	ENSG00000118058
Virus	HIV
Gene Type	protein coding
HPA Location Info	Nucleoplasm;Cytosol;
HPA Protein Class Info	Cancer-related genes, Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Transcription factors
Gene Function	Oncogene
Uniport_ID	Q03164
HGNC ID	HGNC:7132
VEGA ID	OTTHUMG00000166337
OMIM ID	159555
String ID	9606.ENSP00000436786
PharmGKB ID	PA241

Target gene [KMT2A] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4002363	chr11	5	93		98	View
4002988	chr11	56	17		73	View
4003341	chr11	8	51	4	63	View
4004752	chr11	15	16	9	40	View
4006813	chr11	7	12	3	22	View
4007101	chr11	11	10		21	View
4007545	chr11	18	1		19	View
4010000	chr11	7	3		10	View
4010679	chr11	6	2		8	View
4016576	chr11				0	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of KMT2A expression and immune infiltrating cell level correlation result in HIV+ samples
KMT2A expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).