HIV Target gene Detail Information

> KLRG1 Gene Search Result

Gene Information

Gene Name	KLRG1
Gene ID	10219
Gene Full Name	killer cell lectin like receptor G1
Gene Alias	2F1; MAFA; MAFA-L; CLEC15A; MAFA-2F1; MAFA-LIKE
Transcripts	ENSG00000139187
Virus	HIV
Gene Type	protein coding
HPA Location Info	Vesicles;
Membrane Info	Predicted membrane proteins
HPA Protein Class Info	Predicted intracellular proteins, Predicted membrane proteins
Uniport_ID	Q96E93
HGNC ID	HGNC:6380
VEGA ID	OTTHUMG00000168277
OMIM ID	604874
String ID	9606.ENSP00000349477
PharmGKB ID	PA30170

Target gene [KLRG1] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4004885	chr12	38			38	View
4008758	chr12	14			14	View
4013146	chr12	2	2		4	View
4016182	chr12				0	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of KLRG1 expression and immune infiltrating cell level correlation result in HIV+ samples
KLRG1 expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of KLRG1 expression and immune infiltrating cell level correlation result in HIV+ samples
KLRG1 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).