HTLV1 Target gene Detail Information

> KLK1 Gene Search Result

Gene Information

Gene Name	KLK1
Gene ID	3816
Gene Full Name	kallikrein 1
Gene Alias	hK1; KLKR; Klk6
Transcripts	ENSG00000167748
Virus	HTLV1
Gene Type	protein coding
HPA Location Info
HPA Protein Class Info	Enzymes, FDA approved drug targets, Predicted secreted proteins
Uniport_ID	P06870
HGNC ID	HGNC:6357
VEGA ID	OTTHUMG00000182876
OMIM ID	147910
String ID	9606.ENSP00000301420
Drugbank ID	BE0001091
PharmGKB ID	PA224

Target gene [KLK1] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
6002018	chr19	195	85	19	299	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE55851 (GEO)	Adult T-cell leukemia	21	Normal (3), Asymptomatic carriers (HTLV1+)(6), Adult T-cell Leukemia-lymphoma (HTLV1+)(12)
GSE29312 (GEO)	HTLV-1 associated myelopathy	39	Normal (9), Asymptomatic carriers (HTLV1+)(20), HTLV-1-associated myelopathy (HTLV1+)(10)
GSE29332 (GEO)	HTLV-1 associated myelopathy	35	Normal (8), Asymptomatic carriers (HTLV1+)(17), HTLV-1-associated myelopathy (HTLV1+)(10)

> Dataset: GSE55851
HeatMap of cell type fractions in all samples	Lollipop of KLK1 expression and immune infiltrating cell level correlation result in HTLV1+ samples
KLK1 expression: Low -> High

> Dataset: GSE29312
HeatMap of cell type fractions in all samples	Lollipop of KLK1 expression and immune infiltrating cell level correlation result in HTLV1+ samples
KLK1 expression: Low -> High

> Dataset: GSE29332
HeatMap of cell type fractions in all samples	Lollipop of KLK1 expression and immune infiltrating cell level correlation result in HTLV1+ samples
KLK1 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).