HIV Target gene Detail Information

> KLHL5 Gene Search Result

Gene Information

Gene Name	KLHL5
Gene ID	51088
Gene Full Name	kelch like family member 5
Transcripts	ENSG00000109790
Virus	HIV
Gene Type	protein coding
HPA Location Info
Membrane Info	Predicted membrane proteins
HPA Protein Class Info	Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins
Uniport_ID	Q96PQ7
HGNC ID	HGNC:6356
VEGA ID	OTTHUMG00000097819
OMIM ID	608064
String ID	9606.ENSP00000423897
PharmGKB ID	PA30146

Target gene [KLHL5] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4008707	chr4	7	7		14	View
4011257	chr4		5	2	7	View
4014218	chr4		1	1	2	View
4016344	chr4				0	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of KLHL5 expression and immune infiltrating cell level correlation result in HIV+ samples
KLHL5 expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of KLHL5 expression and immune infiltrating cell level correlation result in HIV+ samples
KLHL5 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).