HPV Target gene Detail Information

> KLHL4 Gene Search Result

Gene Information

Gene Name	KLHL4
Gene ID	56062
Gene Full Name	kelch like family member 4
Gene Alias	KHL4; DKELCHL
Transcripts	ENSG00000102271
Virus	HPV
Gene Type	protein coding
HPA Location Info	Microtubules;Centriolar satellite;
HPA Protein Class Info	Predicted intracellular proteins
Uniport_ID	Q9C0H6
HGNC ID	HGNC:6355
VEGA ID	OTTHUMG00000021946
OMIM ID	300348
String ID	9606.ENSP00000362206
PharmGKB ID	PA30145

Target gene [KLHL4] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
5200805	chrX			2	2	View
5201145	chrX				0	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE140662 (GEO)	Condyloma Acuminatum	8	Condyloma acuminata (HPV+)(5), Skin(3)
GSE65858 (GEO)	Head and neck squamous cell carcinoma	270	Head and neck squamous cell carcinoma (EBV+)(73), Head and neck squamous cell carcinoma (EBV-)(197)
GSE55546 (GEO)	Oropharyngeal squamous cell carcinoma	16	Oropharyngeal cancers (HPV+)(12), Normal (4)
GSE55544 (GEO)	Oropharyngeal squamous cell carcinoma	23	Oropharyngeal cancers HPV Active (11), Oropharyngeal cancers HPV Inactive (4), Oropharyngeal cancers HPV Negative (8)
GSE55542 (GEO)	Oropharyngeal squamous cell carcinoma	36	Oropharyngeal cancers HPV Active (12), Oropharyngeal cancers HPV Inactive (8), Oropharyngeal cancers HPV Negative (16)
GSE51993 (GEO)	Cervical intraepithelial neoplasia	24	Cervical intraepithelial neoplasia (HPV+)(17), Normal(7)
HNSC (TCGA)	Head and Neck squamous cell carcinoma	566	Head and Neck squamous cell carcinoma(HPV-)(483),Head and Neck squamous cell carcinoma(HPV+)(39),Paracancerous(HPV-)(44)

> Dataset: GSE140662
HeatMap of cell type fractions in all samples	Lollipop of KLHL4 expression and immune infiltrating cell level correlation result in HPV+ samples
KLHL4 expression: Low -> High

> Dataset: GSE65858
HeatMap of cell type fractions in all samples	Lollipop of KLHL4 expression and immune infiltrating cell level correlation result in HPV+ samples
KLHL4 expression: Low -> High

> Dataset: GSE55546
HeatMap of cell type fractions in all samples	Lollipop of KLHL4 expression and immune infiltrating cell level correlation result in HPV+ samples
KLHL4 expression: Low -> High

> Dataset: GSE55544
HeatMap of cell type fractions in all samples	Lollipop of KLHL4 expression and immune infiltrating cell level correlation result in HPV+ samples
KLHL4 expression: Low -> High

> Dataset: GSE55542
HeatMap of cell type fractions in all samples	Lollipop of KLHL4 expression and immune infiltrating cell level correlation result in HPV+ samples
KLHL4 expression: Low -> High

> Dataset: GSE51993
HeatMap of cell type fractions in all samples	Lollipop of KLHL4 expression and immune infiltrating cell level correlation result in HPV+ samples
KLHL4 expression: Low -> High

> Dataset: HNSC
HeatMap of cell type fractions in all samples	Lollipop of KLHL4 expression and immune infiltrating cell level correlation result in HPV+ samples
KLHL4 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).

> Dataset: GSE140662