HIV Target gene Detail Information

> KLHL3 Gene Search Result

Gene Information

Gene Name	KLHL3
Gene ID	26249
Gene Full Name	kelch like family member 3
Gene Alias	PHA2D
Transcripts	ENSG00000146021
Virus	HIV
Gene Type	protein coding
HPA Location Info
HPA Protein Class Info	Disease related genes, Predicted intracellular proteins
Uniport_ID	Q9UH77
HGNC ID	HGNC:6354
VEGA ID	OTTHUMG00000129155
OMIM ID	605775
String ID	9606.ENSP00000312397
PharmGKB ID	PA30144

Target gene [KLHL3] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4010602	chr5	7		1	8	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of KLHL3 expression and immune infiltrating cell level correlation result in HIV+ samples
KLHL3 expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of KLHL3 expression and immune infiltrating cell level correlation result in HIV+ samples
KLHL3 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).