HTLV1 Target gene Detail Information

> KLHL28 Gene Search Result

Gene Information

Gene Name	KLHL28
Gene ID	54813
Gene Full Name	kelch like family member 28
Gene Alias	BTBD5
Transcripts	ENSG00000179454
Virus	HTLV1
Gene Type	protein coding
HPA Location Info	Cytosol;
HPA Protein Class Info	Predicted intracellular proteins
Uniport_ID	Q9NXS3
HGNC ID	HGNC:19741
VEGA ID	OTTHUMG00000140263
String ID	9606.ENSP00000379434
PharmGKB ID	PA162393472

Target gene [KLHL28] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
6021872	chr14	4	1		5	View
6022661	chr14	4	1		5	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE55851 (GEO)	Adult T-cell leukemia	21	Normal (3), Asymptomatic carriers (HTLV1+)(6), Adult T-cell Leukemia-lymphoma (HTLV1+)(12)
GSE29312 (GEO)	HTLV-1 associated myelopathy	39	Normal (9), Asymptomatic carriers (HTLV1+)(20), HTLV-1-associated myelopathy (HTLV1+)(10)

> Dataset: GSE55851
HeatMap of cell type fractions in all samples	Lollipop of KLHL28 expression and immune infiltrating cell level correlation result in HTLV1+ samples
KLHL28 expression: Low -> High

> Dataset: GSE29312
HeatMap of cell type fractions in all samples	Lollipop of KLHL28 expression and immune infiltrating cell level correlation result in HTLV1+ samples
KLHL28 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).