HIV Target gene Detail Information

> KLHL22 Gene Search Result

Gene Information

Gene Name	KLHL22
Gene ID	84861
Gene Full Name	kelch like family member 22
Gene Alias	KELCHL
Transcripts	ENSG00000099910
Virus	HIV
Gene Type	protein coding
HPA Location Info	Cytokinetic bridge;Microtubules;Mitotic spindle;Vesicles;
HPA Protein Class Info	Disease related genes, Predicted intracellular proteins
Uniport_ID	Q53GT1
HGNC ID	HGNC:25888
VEGA ID	OTTHUMG00000188269
OMIM ID	618020
String ID	9606.ENSP00000331682
PharmGKB ID	PA142671574

Target gene [KLHL22] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4003499	chr22	59	1		60	View
4006696	chr22	3	20		23	View
4012969	chr22	2	2		4	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of KLHL22 expression and immune infiltrating cell level correlation result in HIV+ samples
KLHL22 expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of KLHL22 expression and immune infiltrating cell level correlation result in HIV+ samples
KLHL22 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).