HIV Target gene Detail Information

> KLHL15 Gene Search Result

Gene Information

Gene Name	KLHL15
Gene ID	80311
Gene Full Name	kelch like family member 15
Gene Alias	HEL-S-305
Transcripts	ENSG00000174010
Virus	HIV
Gene Type	protein coding
HPA Location Info	Cytosol;Aggresome;
HPA Protein Class Info	Disease related genes, Predicted intracellular proteins
Uniport_ID	Q96M94
HGNC ID	HGNC:29347
VEGA ID	OTTHUMG00000021261
OMIM ID	300980
String ID	9606.ENSP00000332791
PharmGKB ID	PA134934728

Target gene [KLHL15] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4008105	chrX	16			16	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of KLHL15 expression and immune infiltrating cell level correlation result in HIV+ samples
KLHL15 expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of KLHL15 expression and immune infiltrating cell level correlation result in HIV+ samples
KLHL15 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).