HTLV1 Target gene Detail Information

> KLHDC2 Gene Search Result

Gene Information

Gene Name	KLHDC2
Gene ID	23588
Gene Full Name	kelch domain containing 2
Gene Alias	LCP; HCLP1; HCLP-1
Transcripts	ENSG00000165516
Virus	HTLV1
Gene Type	protein coding
HPA Location Info	Nuclear membrane;Nucleoplasm;Nuclear bodies;
HPA Protein Class Info	Predicted intracellular proteins
Uniport_ID	Q9Y2U9
HGNC ID	HGNC:20231
VEGA ID	OTTHUMG00000140288
OMIM ID	611280
String ID	9606.ENSP00000298307
PharmGKB ID	PA134924955

Target gene [KLHDC2] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
6014173	chr14	17			17	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE55851 (GEO)	Adult T-cell leukemia	21	Normal (3), Asymptomatic carriers (HTLV1+)(6), Adult T-cell Leukemia-lymphoma (HTLV1+)(12)
GSE29312 (GEO)	HTLV-1 associated myelopathy	39	Normal (9), Asymptomatic carriers (HTLV1+)(20), HTLV-1-associated myelopathy (HTLV1+)(10)
GSE29332 (GEO)	HTLV-1 associated myelopathy	35	Normal (8), Asymptomatic carriers (HTLV1+)(17), HTLV-1-associated myelopathy (HTLV1+)(10)

> Dataset: GSE55851
HeatMap of cell type fractions in all samples	Lollipop of KLHDC2 expression and immune infiltrating cell level correlation result in HTLV1+ samples
KLHDC2 expression: Low -> High

> Dataset: GSE29312
HeatMap of cell type fractions in all samples	Lollipop of KLHDC2 expression and immune infiltrating cell level correlation result in HTLV1+ samples
KLHDC2 expression: Low -> High

> Dataset: GSE29332
HeatMap of cell type fractions in all samples	Lollipop of KLHDC2 expression and immune infiltrating cell level correlation result in HTLV1+ samples
KLHDC2 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).