HIV Target gene Detail Information

> KLF5 Gene Search Result

Gene Information

Gene Name	KLF5
Gene ID	688
Gene Full Name	Kruppel like factor 5
Gene Alias	CKLF; IKLF; BTEB2
Transcripts	ENSG00000102554
Virus	HIV
Gene Type	protein coding
HPA Location Info	Nucleoplasm;Golgi apparatus;Vesicles;
HPA Protein Class Info	Cancer-related genes, Predicted intracellular proteins, Transcription factors
Gene Function	Suppressor gene & Oncogene
Uniport_ID	Q13887
HGNC ID	HGNC:6349
VEGA ID	OTTHUMG00000017074
OMIM ID	602903
String ID	9606.ENSP00000366915
PharmGKB ID	PA30139

Target gene [KLF5] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4004889	chr13	38			38	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of KLF5 expression and immune infiltrating cell level correlation result in HIV+ samples
KLF5 expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of KLF5 expression and immune infiltrating cell level correlation result in HIV+ samples
KLF5 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).