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HBV Target gene Detail Information

> KLF4 Gene Search Result


Gene Information
Gene Name KLF4
Gene ID 9314
Gene Full Name Kruppel like factor 4
Gene Alias EZF; GKLF
Transcripts ENSG00000136826
Virus HBV
Gene Type protein coding
HPA Location Info Nucleoplasm;
HPA Protein Class Info Cancer-related genes, Predicted intracellular proteins, Transcription factors
Gene Function Suppressor gene & Oncogene
Uniport_ID O43474
HGNC ID HGNC:6348
VEGA ID OTTHUMG00000020449
OMIM ID 602253
String ID 9606.ENSP00000363804
PharmGKB ID PA30138
Target gene [KLF4] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
1000420 chr9 277 907 1210 2394 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
GSE114783 (GEO) Chronic HBV (CHB) infection 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO) Hepatocellular carcinoma 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO) Liver cirrhosis 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
LIHC (TCGA) Liver hepatocellular carcinoma 424 Liver hepatocellular carcinoma HCV (HBV+)(86), Liver hepatocellular carcinoma HCV (HBV-)(19), Liver hepatocellular carcinoma (HBV+)(209), Liver hepatocellular carcinoma (HBV+)(60), Paracancerous HCV (HBV+)(4), Paracancerous (HBV-)(28), Paracancerous (HBV+)(18)

> Dataset: GSE114783

HeatMap of cell type fractions in all samples Lollipop of KLF4 expression and immune infiltrating cell level correlation result in HBV+ Chronic HBV (CHB) infection samples
KLF4 expression: Low -> High
Lollipop of KLF4 expression and immune infiltrating cell level correlation result in HBV+ Liver cirrhosis samples Lollipop of KLF4 expression and immune infiltrating cell level correlation result in HBV+ Hepatocellular carcinoma samples

> Dataset: LIHC

HeatMap of cell type fractions in all samples Lollipop of KLF4 expression and immune infiltrating cell level correlation result in HBV+ samples
KLF4 expression: Low -> High
Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).