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HBV Target gene Detail Information

> KLF3 Gene Search Result


Gene Information
Gene Name KLF3
Gene ID 51274
Gene Full Name Kruppel like factor 3
Gene Alias BKLF
Transcripts ENSG00000109787
Virus HBV
Gene Type protein coding
HPA Location Info Nucleoplasm;
HPA Protein Class Info Predicted intracellular proteins, Transcription factors
Uniport_ID P57682
HGNC ID HGNC:16516
VEGA ID OTTHUMG00000097821
OMIM ID 609392
String ID 9606.ENSP00000261438
PharmGKB ID PA30137
Target gene [KLF3] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
1012488 chr4 5 1 6 View
1400306 chr4 27 179 64 270 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
GSE114783 (GEO) Chronic HBV (CHB) infection 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO) Hepatocellular carcinoma 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO) Liver cirrhosis 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
LIHC (TCGA) Liver hepatocellular carcinoma 424 Liver hepatocellular carcinoma HCV (HBV+)(86), Liver hepatocellular carcinoma HCV (HBV-)(19), Liver hepatocellular carcinoma (HBV+)(209), Liver hepatocellular carcinoma (HBV+)(60), Paracancerous HCV (HBV+)(4), Paracancerous (HBV-)(28), Paracancerous (HBV+)(18)

> Dataset: GSE114783

HeatMap of cell type fractions in all samples Lollipop of KLF3 expression and immune infiltrating cell level correlation result in HBV+ Chronic HBV (CHB) infection samples
KLF3 expression: Low -> High
Lollipop of KLF3 expression and immune infiltrating cell level correlation result in HBV+ Liver cirrhosis samples Lollipop of KLF3 expression and immune infiltrating cell level correlation result in HBV+ Hepatocellular carcinoma samples

> Dataset: LIHC

HeatMap of cell type fractions in all samples Lollipop of KLF3 expression and immune infiltrating cell level correlation result in HBV+ samples
KLF3 expression: Low -> High
Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).