HPV Target gene Detail Information

> KLF17 Gene Search Result

Gene Information

Gene Name	KLF17
Gene ID	128209
Gene Full Name	Kruppel like factor 17
Gene Alias	ZNF393; Zfp393
Transcripts	ENSG00000171872
Virus	HPV
Gene Type	protein coding
HPA Location Info
HPA Protein Class Info	Predicted intracellular proteins, Transcription factors
Uniport_ID	Q5JT82
HGNC ID	HGNC:18830
VEGA ID	OTTHUMG00000009664
OMIM ID	609602
String ID	9606.ENSP00000361373
PharmGKB ID	PA134877071

Target gene [KLF17] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
5000192	chr1	11	550	130	691	View
5300091	chr1	7	2		9	View
5300092	chr1	6			6	View
5300093	chr1	3			3	View
5300094	chr1	16	14		30	View
5300095	chr1	17	10	3	30	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE140662 (GEO)	Condyloma Acuminatum	8	Condyloma acuminata (HPV+)(5), Skin(3)
GSE40774 (GEO)	Head and neck squamous cell carcinoma	134	Head and neck Squamous cell carcinomas GLOTTIC LARYNX (EBV-)(2), Head and neck Squamous cell carcinomas HYPOPHARYNX (EBV-)(9), Head and neck Squamous cell carcinomas ORAL CAVITY (EBV-)(23), Head and neck Squamous cell carcinomas ORAL CAVITY (EBV+)(2), Head and neck Squamous cell carcinomas OROPHARYNX (EBV-)(22), Head and neck Squamous cell carcinomas OROPHARYNX (EBV+)(54), Head and neck Squamous cell carcinomas OTHER (EBV+)(1), Head and neck Squamous cell carcinomas SUBGLOTTIC LARYNX (EBV-)(1), Head and neck Squamous cell carcinomas SUPRAGLOTTIC (EBV-)(19), Squamous cell carcinomas SUPRAGLOTTIC (EBV+)(1)
GSE55546 (GEO)	Oropharyngeal squamous cell carcinoma	16	Oropharyngeal cancers (HPV+)(12), Normal (4)
GSE55544 (GEO)	Oropharyngeal squamous cell carcinoma	23	Oropharyngeal cancers HPV Active (11), Oropharyngeal cancers HPV Inactive (4), Oropharyngeal cancers HPV Negative (8)
GSE55542 (GEO)	Oropharyngeal squamous cell carcinoma	36	Oropharyngeal cancers HPV Active (12), Oropharyngeal cancers HPV Inactive (8), Oropharyngeal cancers HPV Negative (16)
GSE51993 (GEO)	Cervical intraepithelial neoplasia	24	Cervical intraepithelial neoplasia (HPV+)(17), Normal(7)
HNSC (TCGA)	Head and Neck squamous cell carcinoma	566	Head and Neck squamous cell carcinoma(HPV-)(483),Head and Neck squamous cell carcinoma(HPV+)(39),Paracancerous(HPV-)(44)

> Dataset: GSE140662
HeatMap of cell type fractions in all samples	Lollipop of KLF17 expression and immune infiltrating cell level correlation result in HPV+ samples
KLF17 expression: Low -> High

> Dataset: GSE40774
HeatMap of cell type fractions in all samples	Lollipop of KLF17 expression and immune infiltrating cell level correlation result in HPV+ samples
KLF17 expression: Low -> High

> Dataset: GSE55546
HeatMap of cell type fractions in all samples	Lollipop of KLF17 expression and immune infiltrating cell level correlation result in HPV+ samples
KLF17 expression: Low -> High

> Dataset: GSE55544
HeatMap of cell type fractions in all samples	Lollipop of KLF17 expression and immune infiltrating cell level correlation result in HPV+ samples
KLF17 expression: Low -> High

> Dataset: GSE55542
HeatMap of cell type fractions in all samples	Lollipop of KLF17 expression and immune infiltrating cell level correlation result in HPV+ samples
KLF17 expression: Low -> High

> Dataset: GSE51993
HeatMap of cell type fractions in all samples	Lollipop of KLF17 expression and immune infiltrating cell level correlation result in HPV+ samples
KLF17 expression: Low -> High

> Dataset: HNSC
HeatMap of cell type fractions in all samples	Lollipop of KLF17 expression and immune infiltrating cell level correlation result in HPV+ samples
KLF17 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).

> Dataset: GSE140662