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HBV Target gene Detail Information

> KLF15 Gene Search Result


Gene Information
Gene Name KLF15
Gene ID 28999
Gene Full Name Kruppel like factor 15
Gene Alias KKLF
Transcripts ENSG00000163884
Virus HBV
Gene Type protein coding
HPA Location Info Nuclear speckles;Nucleoplasm;Vesicles;
HPA Protein Class Info Disease related genes, Predicted intracellular proteins, Transcription factors
Uniport_ID Q9UIH9
HGNC ID HGNC:14536
VEGA ID OTTHUMG00000162689
OMIM ID 606465
String ID 9606.ENSP00000296233
PharmGKB ID PA30134
Target gene [KLF15] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
1009211 chr3 2 15 17 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
GSE114783 (GEO) Chronic HBV (CHB) infection 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO) Hepatocellular carcinoma 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO) Liver cirrhosis 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
LIHC (TCGA) Liver hepatocellular carcinoma 424 Liver hepatocellular carcinoma HCV (HBV+)(86), Liver hepatocellular carcinoma HCV (HBV-)(19), Liver hepatocellular carcinoma (HBV+)(209), Liver hepatocellular carcinoma (HBV+)(60), Paracancerous HCV (HBV+)(4), Paracancerous (HBV-)(28), Paracancerous (HBV+)(18)

> Dataset: GSE114783

HeatMap of cell type fractions in all samples Lollipop of KLF15 expression and immune infiltrating cell level correlation result in HBV+ Chronic HBV (CHB) infection samples
KLF15 expression: Low -> High
Lollipop of KLF15 expression and immune infiltrating cell level correlation result in HBV+ Liver cirrhosis samples Lollipop of KLF15 expression and immune infiltrating cell level correlation result in HBV+ Hepatocellular carcinoma samples

> Dataset: LIHC

HeatMap of cell type fractions in all samples Lollipop of KLF15 expression and immune infiltrating cell level correlation result in HBV+ samples
KLF15 expression: Low -> High
Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).