HIV Target gene Detail Information

> KIT Gene Search Result

Gene Information

Gene Name	KIT
Gene ID	3815
Gene Full Name	KIT proto-oncogene receptor tyrosine kinase
Gene Alias	PBT; SCFR; C-Kit; CD117; MASTC
Transcripts	ENSG00000157404
Virus	HIV
Gene Type	protein coding
HPA Location Info	Plasma membrane;
Membrane Info	Predicted membrane proteins
HPA Protein Class Info	Cancer-related genes, CD markers, Disease related genes, Enzymes, FDA approved drug targets, Plasma proteins, Predicted membrane proteins, RAS pathway related proteins
Gene Function	Oncogene
Uniport_ID	P10721
HGNC ID	HGNC:6342
VEGA ID	OTTHUMG00000128713
OMIM ID	164920
String ID	9606.ENSP00000288135
Drugbank ID	BE0000453
PharmGKB ID	PA30128
FDA Approved Drug	Imatinib;Midostaurin

Target gene [KIT] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4009628	chr4	4	7		11	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of KIT expression and immune infiltrating cell level correlation result in HIV+ samples
KIT expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of KIT expression and immune infiltrating cell level correlation result in HIV+ samples
KIT expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).