HTLV1 Target gene Detail Information

> KHDC1 Gene Search Result

Gene Information

Gene Name	KHDC1
Gene ID	80759
Gene Full Name	KH domain containing 1
Gene Alias	NDG1; KHDC1L; C6orf147; C6orf148; bA257K9.4; Em:AC019205.8
Transcripts	ENSG00000135314
Virus	HTLV1
Gene Type	protein coding
HPA Location Info	Cytosol;Mitochondria;
Membrane Info	Predicted membrane proteins
HPA Protein Class Info	Predicted intracellular proteins, Predicted membrane proteins
Uniport_ID	Q4VXA5
HGNC ID	HGNC:21366
VEGA ID	OTTHUMG00000015030
OMIM ID	611688
String ID	9606.ENSP00000359411
PharmGKB ID	PA162392802

Target gene [KHDC1] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
6000052	chr6	3667	1588	1099	6354	View
6000316	chr6	1522	409	219	2150	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE55851 (GEO)	Adult T-cell leukemia	21	Normal (3), Asymptomatic carriers (HTLV1+)(6), Adult T-cell Leukemia-lymphoma (HTLV1+)(12)
GSE29312 (GEO)	HTLV-1 associated myelopathy	39	Normal (9), Asymptomatic carriers (HTLV1+)(20), HTLV-1-associated myelopathy (HTLV1+)(10)

> Dataset: GSE55851
HeatMap of cell type fractions in all samples	Lollipop of KHDC1 expression and immune infiltrating cell level correlation result in HTLV1+ samples
KHDC1 expression: Low -> High

> Dataset: GSE29312
HeatMap of cell type fractions in all samples	Lollipop of KHDC1 expression and immune infiltrating cell level correlation result in HTLV1+ samples
KHDC1 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).