HIV Target gene Detail Information

> KDM5B Gene Search Result

Gene Information

Gene Name	KDM5B
Gene ID	10765
Gene Full Name	lysine demethylase 5B
Gene Alias	CT31; PLU1; PUT1; MRT65; PLU-1; JARID1B; PPP1R98; RBP2-H1; RBBP2H1A
Transcripts	ENSG00000117139
Virus	HIV
Gene Type	protein coding
HPA Location Info	Nucleoplasm;Cytosol;
HPA Protein Class Info	Predicted intracellular proteins, Transcription factors
Gene Function	Oncogene
Uniport_ID	Q9UGL1
HGNC ID	HGNC:18039
VEGA ID	OTTHUMG00000041401
OMIM ID	605393
String ID	9606.ENSP00000356234
PharmGKB ID	PA164721626

Target gene [KDM5B] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4002336	chr1	21	14	65	100	View
4006066	chr1	24	3		27	View
4008123	chr1	15	1		16	View
4010660	chr1	4	4		8	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of KDM5B expression and immune infiltrating cell level correlation result in HIV+ samples
KDM5B expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of KDM5B expression and immune infiltrating cell level correlation result in HIV+ samples
KDM5B expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).