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HTLV1 Target gene Detail Information

> KCNT1 Gene Search Result


Gene Information
Gene Name KCNT1
Gene ID 57582
Gene Full Name potassium sodium-activated channel subfamily T member 1
Gene Alias ENFL5; SLACK; EIEE14; KCa4.1; Slo2.2; bA100C15.2
Transcripts ENSG00000107147
Virus HTLV1
Gene Type protein coding
HPA Location Info
Membrane Info Predicted membrane proteins
HPA Protein Class Info Disease related genes, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters, Voltage-gated ion channels
Uniport_ID Q5JUK3
HGNC ID HGNC:18865
VEGA ID OTTHUMG00000020917
OMIM ID 608167
String ID 9606.ENSP00000360822
PharmGKB ID PA38725
Target gene [KCNT1] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
6006951 chr9 51 9 1 61 View
6008335 chr9 5 11 30 46 View
6011587 chr9 24 2 26 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
GSE55851 (GEO) Adult T-cell leukemia 21 Normal (3), Asymptomatic carriers (HTLV1+)(6), Adult T-cell Leukemia-lymphoma (HTLV1+)(12)
GSE29312 (GEO) HTLV-1 associated myelopathy 39 Normal (9), Asymptomatic carriers (HTLV1+)(20), HTLV-1-associated myelopathy (HTLV1+)(10)
GSE29332 (GEO) HTLV-1 associated myelopathy 35 Normal (8), Asymptomatic carriers (HTLV1+)(17), HTLV-1-associated myelopathy (HTLV1+)(10)

> Dataset: GSE55851

HeatMap of cell type fractions in all samples Lollipop of KCNT1 expression and immune infiltrating cell level correlation result in HTLV1+ samples
KCNT1 expression: Low -> High

> Dataset: GSE29312

HeatMap of cell type fractions in all samples Lollipop of KCNT1 expression and immune infiltrating cell level correlation result in HTLV1+ samples
KCNT1 expression: Low -> High

> Dataset: GSE29332

HeatMap of cell type fractions in all samples Lollipop of KCNT1 expression and immune infiltrating cell level correlation result in HTLV1+ samples
KCNT1 expression: Low -> High
Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).