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HTLV1 Target gene Detail Information

> KCNQ2 Gene Search Result


Gene Information
Gene Name KCNQ2
Gene ID 3785
Gene Full Name potassium voltage-gated channel subfamily Q member 2
Gene Alias EBN; BFNC; EBN1; ENB1; HNSPC; KV7.2; KCNA11
Transcripts ENSG00000281151
Virus HTLV1
Gene Type protein coding
HPA Location Info Endoplasmic reticulum;
Membrane Info Predicted membrane proteins
HPA Protein Class Info Disease related genes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, Transporters, Voltage-gated ion channels
Uniport_ID O43526
HGNC ID HGNC:6296
VEGA ID OTTHUMG00000190285
OMIM ID 602235
String ID 9606.ENSP00000352035
Drugbank ID BE0000897; BE0009847
PharmGKB ID PA30074
Target gene [KCNQ2] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
6010103 chr20 27 6 33 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
GSE55851 (GEO) Adult T-cell leukemia 21 Normal (3), Asymptomatic carriers (HTLV1+)(6), Adult T-cell Leukemia-lymphoma (HTLV1+)(12)
GSE29312 (GEO) HTLV-1 associated myelopathy 39 Normal (9), Asymptomatic carriers (HTLV1+)(20), HTLV-1-associated myelopathy (HTLV1+)(10)
GSE29332 (GEO) HTLV-1 associated myelopathy 35 Normal (8), Asymptomatic carriers (HTLV1+)(17), HTLV-1-associated myelopathy (HTLV1+)(10)

> Dataset: GSE55851

HeatMap of cell type fractions in all samples Lollipop of KCNQ2 expression and immune infiltrating cell level correlation result in HTLV1+ samples
KCNQ2 expression: Low -> High

> Dataset: GSE29312

HeatMap of cell type fractions in all samples Lollipop of KCNQ2 expression and immune infiltrating cell level correlation result in HTLV1+ samples
KCNQ2 expression: Low -> High

> Dataset: GSE29332

HeatMap of cell type fractions in all samples Lollipop of KCNQ2 expression and immune infiltrating cell level correlation result in HTLV1+ samples
KCNQ2 expression: Low -> High
Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).