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HTLV1 Target gene Detail Information

> KCNQ1 Gene Search Result


Gene Information
Gene Name KCNQ1
Gene ID 3784
Gene Full Name potassium voltage-gated channel subfamily Q member 1
Gene Alias LQT; RWS; WRS; LQT1; SQT2; ATFB1; ATFB3; JLNS1; KCNA8; KCNA9; Kv1.9; Kv7.1; KVLQT1
Transcripts ENSG00000282076
Virus HTLV1
Gene Type protein coding
HPA Location Info
Membrane Info Predicted membrane proteins
HPA Protein Class Info Disease related genes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, Transporters, Voltage-gated ion channels
Uniport_ID P51787
HGNC ID HGNC:6294
VEGA ID OTTHUMG00000190747
OMIM ID 607542
String ID 9606.ENSP00000155840
Drugbank ID BE0000672; BE0009847
PharmGKB ID PA223
Target gene [KCNQ1] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
6005077 chr11 15 75 6 96 View
6005078 chr11 15 75 6 96 View
6005405 chr11 19 54 15 88 View
6006670 chr11 60 4 1 65 View
6014200 chr11 4 8 5 17 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
GSE55851 (GEO) Adult T-cell leukemia 21 Normal (3), Asymptomatic carriers (HTLV1+)(6), Adult T-cell Leukemia-lymphoma (HTLV1+)(12)
GSE29312 (GEO) HTLV-1 associated myelopathy 39 Normal (9), Asymptomatic carriers (HTLV1+)(20), HTLV-1-associated myelopathy (HTLV1+)(10)
GSE29332 (GEO) HTLV-1 associated myelopathy 35 Normal (8), Asymptomatic carriers (HTLV1+)(17), HTLV-1-associated myelopathy (HTLV1+)(10)

> Dataset: GSE55851

HeatMap of cell type fractions in all samples Lollipop of KCNQ1 expression and immune infiltrating cell level correlation result in HTLV1+ samples
KCNQ1 expression: Low -> High

> Dataset: GSE29312

HeatMap of cell type fractions in all samples Lollipop of KCNQ1 expression and immune infiltrating cell level correlation result in HTLV1+ samples
KCNQ1 expression: Low -> High

> Dataset: GSE29332

HeatMap of cell type fractions in all samples Lollipop of KCNQ1 expression and immune infiltrating cell level correlation result in HTLV1+ samples
KCNQ1 expression: Low -> High
Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).